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Saffron

Contact information

Adderss:
Unit#E,2nd Floor No.55,Allameh Tower, North Allameh St, East Sarv St.kaj Square,Saadat-Abad Ave,Tehran, Iran

Post code :
1997855449

Tel:
+9821 - 22365723 +9821 - 22365724

Fax:
+9821 – 89774992

info@irandriedfruit.com

Kashmiri & Iranian saffron - a comparison

The main difference between Kashmiri and Iranian Saffron is that of the yield of Stigmas which is about 75%.The excess yield is due to the fact that the stigmas of saffron cultivated in Kashmir are extremely long and with a thick head. They are also of a deep red color. The size of the stigmas indicates the inherent suitability of the soil and climate for this product.
Thus by just physically observing the saffron its origin can be identified provided it has not been blended with saffron from various origins. The blending is normally done by importers in non producing countries because of the wide disparities in prices: the Iranian Saffron is about 1/2 the price of Kashmiri Saffron.

Medicinal use

Persian saffronSaffron's traditional folkloric uses as an herbal medicine are legendary. It has been used for its carminative and emmenagogic properties, for example. Iranian used saffron to treat respiratory infections and disorders such as coughs and common colds,smallpox, cancer, hypoxia, and asthma. Other targets included blood disorders, insomnia, paralysis, heart diseases, flatulence, stomach upsets and disorders, gout, chronic uterine haemorrhage, dysmorrhea, amenorrhea, baby colic, and eye disorders.
For ancient Persians, saffron was also an aphrodisiac, a general-use antidote against poisoning, a digestive stimulant, and a tonic for dysentery and measles.
Saffron's arytenoids have been shown in scientific studies to have ant carcinogenic (cancer-suppressing), anti-mutagenic (mutation-preventing), and immune-modulating properties.
The active ingredient behind these effects has been identified as dimethyl-crocetin. This compound counters a wide spectrum of both murine tumours as well as human leukaemia cancer cell lines.
Saffron extract also delays ascites tumour growth, delays papilla carcinogenesis, inhibited squalors cell carcinoma, and decreases the incidence of soft tissue sarcoma in treated mice.
Researcher’s theories that such anticancer activity can be best attributed to dimethyl-crocetin's disruption of the DNA-binding ability of proteins, as shown in Thymidine-uptake studies.
Specifically, the DNA-binding ability of enzymes known as type II topoisomerases within cancer cells is inhibited.] Thus, the malignant cells are unable to synthesize or replicate their own DNA.

Saffron's pharmacological effects on malignant tumours have been documented in studies done both in vitro and in vivo. For example, saffron extends the lives of mice that are intraperitoneally impregnated with transplanted sarcomas, namely, samples of S-180, Dalton's lymphoma ascites (DLA), and Ehrlich ascites carcinoma (EAC) tumours.

Researchers followed this by orally administering 200 mg of saffron extract per each kg of mouse body weight. As a result the life spans of the tumour-bearing mice were extended to 111.0%, 83.5%, and 112.5%, respectively, in relation to baseline spans.

Researchers also discovered that saffron extract exhibits cytotoxicity in relation to DLA, EAC, P38B, and S-180 tumour cell lines cultured in vitro. Thus, saffron has shown promise as a new and alternative treatment for a variety of cancers.

Besides wound-healing and anticancer properties, saffron is also an antioxidant. This means that, as an "anti-aging" agent, it neutralises free radicals. Specifically, methanol extractions of saffron neutralise at high rates the DPPH (IUPAC nomenclature: 1,1-diphenyl-2-picrylhydrazyl) radicals.

This occurred via vigorous proton donation to DPPH by two of saffron's active agents, safranal and crocin. Thus, at concentrations of 500 and 1000 ppm, crocin studies showed neutralisation of 50% and 65% of radicals, respectively. Safranal displayed a lesser rate of radical neutralisation than crocin, however.
Such properties give saffron extracts promise as an ingredient for use as an antioxidant in pharmaceuticals, cosmetics, and as a food supplement. Ingested at high enough doses, however, saffron is lethal. Several studies done on lab animals have shown that saffron's LD50 (semi-lethal dose, or the dose at which 50% of test animals die from overdose) is 20.7 g/kg when delivered via a decoction.

Some useful information about saffron

 

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